Cell-Matrix Mechanics

Course Info

Course Number/Code: 3.97J (Spring 2004)
Course Title: Cell-Matrix Mechanics
Course Level: Graduate
Offered By: Massachusetts Institute of Technology (MIT)
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Department: Health Sciences and Technology
Course Instructor(s): Prof. Myron Spector
Prof. Ioannis Yannas
Course Introduction:
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Course Topics

Response of cells and tissues to exogenous mechanical loading.Endogenous mechanical forces generated by cells (viz., contractile forces generated by connective tissue cells).Molecular structure-mechanical properties relationships for selected connective tissues.Chemical composition of the extracellular matrix of tissues.Structure of tissues (viz., connective tissues) at the nanometer, micrometer, and millimeter length scales (including the hierarchical structure of tissues).Load-deformation behavior of tissues at the micrometer and millimeter scales.Interrelationships among the above.

Unique Aspects of the Subject

Assessment of the response of cells and tissues to mechanical forces; discussion of mechano-transduction mechanisms.Discussion of contraction of connective tissue cells.

Course Textbook

Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.

This book is supplemented by papers, presentations and readings.

Grading

The course grade is based entirely on the three quizzes.